14 Remarkable Benefits of Alpha GPC + Dosage & How To Take It

(1) https://pubmed.ncbi.nlm.nih.gov/30252380/

The 24 Best Natural Ways to Increase GABA Levels in the Brain

October 22, 2024 Jordan Fallis

I suffered from severe and chronic anxiety and poor sleep for a large chunk of my life.

So I've always been interested in learning how to increase GABA levels and activate GABA receptors in the brain.

What is GABA?

GABA is a neurotransmitter, which is a signaling compound in your nervous system.

It inhibits you, makes you more relaxed, stops you from worrying and overthinking, and reduces anxiety and stress.

GABA stands for Gamma-Aminobutyric Acid.

And it’s the main inhibitory neurotransmitter that you’ll definitely want to increase if you’re striving for optimal brain function and mental health.

Research shows that a reduction in the synthesis and release of GABA can lead to brain dysfunction and poor mental health.

So if you suspect you have low GABA levels, you’ll want to pay close attention to this article.

In it, I explore the 24 best natural ways to increase GABA levels in the brain.

I’ll start by sharing my top 10 favorites. They have personally worked well for me in the past.

Then I’ll give you 14 other decent options as well.

Read on to learn more.

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What Is GABA and What Does It Do in the Brain?

In the past, I’ve written articles about how to increase dopamine levels, enhance acetylcholine, and boost oxytocin levels in the brain.

And, like GABA, these compounds are neurotransmitters (at least in part).

But GABA has other functions.

It’s also an amino acid, which is a building block of protein.

But for today’s article, these other functions aren’t that important.

As a neurotransmitter, the main goal of GABA is inhibition.

GABA opposes “glutamate” in the nervous system, and glutamate promotes activation.

So you can imagine GABA as the break of a car, and glutamate is the gas pedal (1-6).

A common way many people influence their GABA system and quickly increase GABA levels in their brain is by drinking alcohol (7-11).

Although the real physiological effects are more complex, part of the reason most people feel very relaxed drinking alcohol is because it raises GABA levels and activates GABA receptors in the brain.

The same is true for benzodiazepines or “benzos”, which are a category of anti-anxiety and anti-insomnia drugs (12-16).

Obviously, there are problems with both of these approaches.

Sure, you can rely on alcohol and benzos to feel calm and relaxed fast.

But it’s not a particularly productive long-term strategy, as both interventions can be extremely addictive and come with side effects (17-25).

I personally struggled with alcohol and benzo addiction myself. It’s not a fun path to go down.

What’s more, GABA plays a major role in the withdrawal of alcohol and benzos.

So, either way you look at it, you’ll need a natural solution to increase GABA in your brain if you want to avoid alcohol and benzos or if you want to come off of them and minimize severe withdrawal symptoms.

By naturally increasing GABA levels in the brain, you can experience the following benefits:

Lowers stress and anxiety - Stress lowers GABA levels in some parts of your brain. But the opposite is also true. When you increase GABA levels, stress levels go down. Even during an acute stressful period or anxiety episode, increasing GABA will decrease your stress levels (26-30).

Normalises blood pressure and inhibits hypertension - Hypertension, or “high blood pressure”, is very much related to how well your brain functions, especially as you get older. Hypertension and depression are also interrelated in many studies, so it’s important to point out that GABA normalizes blood pressure (31-44).

Decreases your depression risk (45-49).

Lowers stress hormone levels and improves hormone function, although this relationship needs a lot more research. At least in cases of burnout, post-traumatic stress disorder (PTSD), and low testosterone, GABA might play a role (50-53).

Increase in sleep quality - Many different compounds, such as GABA, theanine, and valerian extract, affect GABA levels in the brain. These compounds then enhance sleep quality. You’ll get more deep sleep, spend more time dreaming, and fall asleep quicker. Many prescription drugs that affect GABA are used for sleep purposes as well, but are frequently unsustainable over the long run (54-60).

Enhance cognitive performance - Learning, memory, emotions, and cognitive processing are all affected by GABA. Furthermore, brain development and neurodegenerative diseases are also influenced by the GABA system. In the last decade or so, the focus on GABA research has actually shifted from relaxation alone, and now significantly focuses on cognition as well (61-68).

Decreases psychiatric illness risk - Although the evidence isn’t too strong, schizophrenia and conditions on the autism spectrum might be related to GABA abnormalities in the brain as well (69-72).

My Top 10 Favourite Proven Ways to Naturally Increase GABA Levels in the Brain

1. Meditation

Quite a lot of research has looked into the relationship between meditation and GABA levels in the brain.

It turns out that meditation activates the “prefrontal cortex” in the brain. And when the prefrontal cortex is activated, another brain area called the thalamus increases GABA production (73-76).

By meditating over time, you will build a thicker prefrontal cortex.

The prefrontal cortex steers many higher brain functions, such as planning, inhibition control, and abstract thinking. But, by building this area, you will also improve your brain’s ability to produce GABA (77-80).

But it doesn’t take long to start seeing benefits from meditation.

Researchers have found that a single meditation session leads to measurable improvements in the brain.

This effect happens with many different types of meditation, including mindfulness-styled meditations and “Transcendental Meditation” (75).

Meditation is one of my favourite daily activities and treatments to maintain my mental health.

I recommend the Muse headband to meditate. It gives you real-time feedback while you meditate. It makes meditation a lot more fun and tolerable.

I previously wrote about it here, and you can get it through the Muse website.

2. Magnesium

Magnesium is the “anti-stress mineral” (86).

Magnesium reduces stress through many different mechanisms, such as making you more relaxed, improving the amount of deep sleep you get, and increasing GABA.

Research shows that magnesium increases the activity of GABA receptors in some parts of the brain (86).

Magnesium’s abilify to increase GABA activity is one of the main reasons why magnesium improves sleep, and increases the amount of deep sleep you get (90).

Animal studies also show that magnesium has anti-anxiety effects through the GABA system.

In one study, researchers found that if you take magnesium with a medication that interferes with GABA, there is a significant reduction in the anti-anxiety effects of magnesium (87-88).

It’s also important to point out that magnesium also decreases the activity of the glutamate system (89, 91).

Overactivity of the glutamate system can stimulate panic, anxiety, and fear.

More research is needed to clarify the interaction between GABA, magnesium, and glutamate. Current research is very promising though.

There are a number of things you can do to make sure you’re getting enough magnesium.

First, make sure you’re eating magnesium-rich foods on a regular basis, including:

Spinach
Chard
Pumpkin seeds
Almonds
Avocado
Dark chocolate
Bananas

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

You can also increase your body’s intake of magnesium by taking Epsom salt baths.

Supplementation is also a good idea for most people.

Magnesium is included in this supplement.

3. Zinc

Researchers have studied the relationship between zinc and the brain in great detail.

They have found that zinc is an essential mineral for mental health, especially if you have chronic anxiety.

Zinc plays a major role in both the glutamate and GABA systems. And having sufficient zinc levels in your brain is necessary for optimal GABA levels (100; 105-107).

Here are some good sources of zinc:

Oysters
Grass-fed beef
Pumpkin seeds
Cashews
Mushrooms
Spinach

These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

A severe zinc deficiency is somewhat rare in developed nations, but it’s very prevalent in developing nations (102-104).

Optimal levels are another story, though.

Many people today don’t have optimal levels of zinc, and most people aren’t getting the optimal amount of zinc for their brain function and mental health.

For that reason, I developed the Optimal Zinc supplement, which improves mood and decreases anxiety in many people. Its impact on GABA levels is one of the main reasons for these improvements.

Why should you worry about insufficient zinc intake?

Well, animal studies show that if your zinc intake is too low or insufficient for long enough, it eventually affects the zinc levels in the brain. The excitatory glutamate system can then become more predominant in some brain regions (108).

Zinc also counteracts excessive copper levels. Preliminary evidence shows that excessive copper levels can impede and reduce GABA in the brain (109-111).

Check out my previous post all about zinc and anxiety if you want to learn more about how zinc impacts anxiety levels and can contribute to stress.

Zinc can also stimulate your vagus nerve, which reduces anxiety.

4. Theanine

Theanine is one of the reasons why tea gives you a very relaxed and less stimulating experience than coffee.

Theanine is one of my favourite compounds because it stimulates many different brain signaling compounds (neurotransmitters). These neurotransmitters include dopamine, serotonin, and GABA (112).

Learning and memory also improve when you consume theanine. Theanine inhibits the “jittery” effects of caffeine, giving you a calm focus. The same is true for countering the side effects of cannabis (113-114).

Theanine also protects the brain cells associated with the GABA system. That’s part of the reason why you can use theanine as a cognitive enhancer. Theanine is sometimes used in brain conditions such as ADHD, for that reason (114).

If you’re interested in supplementing with theanine, this anti-anxiety supplement contains it.

5. Taurine

Taurine is an amino acid, a building block for proteins (118).

Taurine is mainly found in animal products such as meats and dairy (119-120).

By increasing your taurine intake, you will also increase both taurine levels and GABA levels in the brain (123).

Many people don’t know that taurine is also famous for its effect on the GABA system in the nervous system (121).

Taurine has widespread effects on brain function. It affects nerve conductivity, promotes the regeneration of the nervous system, acts as an antioxidant, and more (122).

In fact, taurine is now being proposed as a pharmacological compound for pathologies that affect GABA receptors in the brain (122). Alcoholism, depression, and epilepsy come to mind here.

If you’re following a vegetarian diet, and especially if you’re following a vegan diet, I highly recommend supplementing with taurine. Taurine is inexpensive and frequently has positive effects on people’s brain health (124).

A final reason why taurine is important is that it affects your health in general in a significant way (125). How well your body handles blood sugar, heart disease risk, inflammation, and mitochondrial function are all affected by taurine. These domains, in turn, influence your brain health.

Taurine is included in the Optimal Calm supplement.

6. Exercise

Not surprisingly, exercise is another natural way to increase GABA levels in your brain.

A huge number of studies have been carried out on exercise and GABA function in the brain (133-139).

These studies are very difficult to perform on humans in an ethical way because you cannot open a human’s brain up after an experiment.

But animal studies show that exercise disinhibits GABA, resulting in neuroprotective effects. One bout of exercise is already sufficient for rats to receive these positive effects (134).

Research also shows that learning and memory are improved by exercise’s effect on GABA (139).

One of the only human studies investigating the effects of exercise on GABA showed a 20% increase in an area of the brain called the “sensorimotor cortex” (136).

The sensorimotor cortex is one of the main sensory and motor areas of the brain. An improved sensorimotor cortex aids complex thought, movement, and overall brain function (140).

Even though single sessions of exercise support GABA and increase GABA levels in the brain, the gains are also cumulative over time (137).

So it’s important to exercise consistently over a longer period of time. You are more likely to increase and maintain optimal GABA levels that way.

Exercise can be a big chore for a lot of people, so I recommend finding some sort of sport or aerobic activity that you enjoy. That way you won’t get sick of it and you’ll exercise regularly.

Besides boosting GABA levels, exercise can also stimulate the vagus nerve, promote neurogenesis, and increase blood flow to the brain.

Many experts recommend exercise as their number one piece of advice for optimal brain health.

With more research over time, researchers speculate that they’ll better understand the impact of exercise on GABA levels and they will be able to:

“add to a growing understanding of the distinctive brain state associated with physical activity. A more complete understanding of this brain state may reveal important insights into mechanisms underlying the beneficial effects of physical exercise in neuropsychiatric disorders, neurorehabilitation, aging, and cognition.” (138).

7. Epigallocatechin Gallate / Green Tea

Epigallocatechin-3-Gallate (EGCG) is the main polyphenol found in green tea.

It’s been shown to have anti-inflammatory and neuroprotective effects (152).

EGCG also has a mechanism of action similar to benzodiazepine drugs. The compound works well to lower stress and anxiety, mainly by affecting GABA levels in the brain (153-156).

I personally drink organic green tea regularly, usually in place of coffee on days when I’m relaxing.

However, it’s important to keep in mind that the body isn't very good at absorbing EGCG from green tea and distributing it to the brain and other tissues.

That's why researchers often use large dosages of concentrated EGCG in their studies instead of green tea.

But unfortunately, large doses of concentrated EGCG have been shown to cause liver toxicity.

So you could supplement with large dosages of concentrated EGCG and see some benefits.

But you'd be damaging your liver at the same time.

Not good.

So what should you do? How do you absorb EGCG and get the amazing benefits of it without damaging your liver?

You take it with Vitamin C.

Research shows that you can enhance the absorption and availability of EGCG by taking it with Vitamin C.

That's why the Optimal Antiox supplement includes a small and safe amount of EGCG, plus 500 mg of Vitamin C.

This significantly enhances the absorption of EGCG, and ensures you get all the brain and mental health benefits of EGCG (without the harm).

8. Probiotics

Probiotics are an extremely complex topic so I won’t go into too much detail here.

But research suggests that certain probiotics can increase GABA and have a huge effect on the GABA system in your body, depending on the probiotic and strain (188-191).

I’ve formulated a probiotic blend myself, Optimal Biotics, with the goal of increasing GABA levels and lowering stress and anxiety.

If you struggle with anxiety, here are 9 probiotic strains that can help.

And make sure you read my other article on promoting healthy gut bacteria for brain health as well.

9. Vitamin B6

Vitamin B6 is a key nutrient that supports your entire nervous system.

Vitamin B6 is responsible for how well GABA functions in your body (196-199).

As a result, having a deficiency in Vitamin B6 can definitely increase your anxiety.

In fact, Vitamin B6 levels have been shown to be significantly lower in individuals who have anxiety and panic attacks.

And unfortunately, quite a few people are Vitamin B6 deficient nowadays.

The number is as high as 12% in higher socioeconomic settings. In poorer environments, 30% of people or more might have Vitamin B6 insufficiency or deficiency (192-194).

Animal foods and some fruits and vegetables are great sources of Vitamin B6 (195).

Some of the best food sources of Vitamin B6 include potatoes, bananas and chicken.

But if you want to see quick improvements, you may want to try supplementing with Vitamin B6.

When I took antidepressants and benzodiazepines for my chronic anxiety, I took a Vitamin B6 supplement.

This is because psychiatric medication can actually further deplete Vitamin B6, increasing anxiety in the long run.

So if you take medication to manage your anxiety, or simply have anxiety and want to manage it better, I highly recommend supplementing with Vitamin B6.

That’s why I included it in the Optimal Calm supplement.

10. Sunlight

Exposing yourself to sunshine is one of the best natural ways to increase GABA levels in your brain.

When sunlight enters your eyes, it tells your body that it’s daytime. And at night, the absence of sunlight tells your body that you need to sleep, and your body increases the release of melatonin.

As you may be aware, this is called your “circadian rhythm”, and it’s heavily intertwined with GABA in your brain. Different types of light, such as visible light (colours of the rainbow), infrared (heat), and ultraviolet (which can give you sunburns) have different effects on the GABA levels in your brain (141-145).

Unfortunately, right now, many of the studies investigating the effects of light on GABA in the brain are animal studies. These animal studies, however, are extremely promising because ultraviolet light shows such a huge effect.

In studies blocking the effect of GABA activity in the brain, the circadian rhythm no longer responds adequately to light (146).

I personally get sunlight every single day to support my GABA and dopamine levels. My recommendation is to get some sunlight exposure in the early morning and in the afternoon. During the afternoon, make sure you get out of the sun before you get a sunburn.

Other Effective Ways to Naturally Increase GABA Levels in the Brain

11. Alpha GPC

Alpha GPC is a source of choline that’s found in both foods and in your body (218-219).

A wide array of animal and plant foods contain tiny amounts of Alpha GPC. The compound is also sold as a supplement.

The GABA system is also affected by Alpha GPC intake. This effect is only confirmed in animal studies so far though (220).

Alpha GPC is also a powerful cognitive enhancer. It boosts dopamine, and has superior effects to caffeine in some studies (221-223).

Alpha GPC is also neuroprotective and likely lowers the risk of diseases such as Alzheimer’s and Parkinson’s.

Alpha GPC is included in the Optimal Brain supplement.

You can also find some choline in beef liver and egg yolks, but it’s better to take Alpha GPC because you get noticeable and immediate benefits.

Make sure you read this article to learn more about the remarkable benefits of Alpha GPC, the optimal dosage, and the best way to take it.

12. Valerian

Valerian (Valeriana officinalis) is a natural herb, and the root of the herb has traditionally been used to treat insomnia.

It’s extremely popular as a sleep medication herb because it has a strong effect on GABA in the brain.

Research shows that it binds to GABA receptors in the amygdala, a brain region associated with fear and anxiety. It also increases GABA levels and inhibits the breakdown of GABA in the brain (157-161).

As a result of this, it creates a calming effect similar to anti-anxiety drugs like Xanax and Valium.

Valerian is sold as an over-the-counter supplement almost anywhere. Taking valerian results in both anti-anxiety, anti-pain, and sedative effects. These effects are perfect for promoting quality sleep.

And those effects mainly occur because of valerian’s abilify to increase GABA levels in the brain.

This is why valerian is often called “Nature’s Valium”.

But unlike EGCG, which I had mentioned earlier, valerian doesn’t exactly mimic benzodiazepines. It has a different mechanism of action.

Valerian is one of the first herbal remedies I took many years ago to manage my anxiety at night and improve my sleep.

It’s included in this anti-anxiety supplement.

Valerian supplements typically include the roots and stems of the plant.

But you can also take it as a tea or tincture if you want.

13. Chamomile

Chamomile is a flowery plant used for herbal infusions. It’s also sold as a supplement.

It contains essential oils and flavonoids that can help you relax.

As a result, chamomile is often used as an anti-anxiety plant or sleep aid (162).

And chamomile’s sedative and anti-anxiety effects almost certainly stem from its effects on GABA (163).

After treating yourself with a standard dose of chamomile for several weeks, it’s likely that your anxiety levels will go down if they were high to begin with (164).

Researchers have found that oral supplementation of chamomile significantly reduces anxiety and stress in patients with generalized anxiety.

Animal studies show that chamomile contains substances that act on the same parts of the brain as anti-anxiety drugs.

Apigenin, one of the main flavonoids in chamomile, reduces anxiety without sedation by enhancing GABA communication.

Chamomile’s effects on sleep are less well-proven and have not been extensively studied yet.

Feverfew, which is extremely similar to chamomile, is often used to counter migraines, and it also affects GABA (180-182).

14. Hops

For many people, hops or “Humulus lupulus” is a favourite compound because it’s found in beer.

An extract of hops has been shown to increase GABA activity in the brain (165).

Hops also works as a sedative by influencing your circadian rhythm, which is the 24-7 day and night cycle in your brain and body.

Researchers have found that it increases sleep duration by increasing GABA (166-168).

The benefits of taking a hops supplement is that you don’t need to drink beer and alcohol to enjoy the relaxing GABA-boosting effect.

15. Lemon Balm

Lemon balm, or Magnolia Officinalis, is yet another herbal extract that increases GABA.

Lemon balm affects both the cannabinoid system and the GABA system, and lowers cortisol and reduces inflammation.

Research shows that lemon balm extract significantly reduces anxiety and stress in humans by increasing GABA levels in the brain (183-187).

As a result, lemon balm can help induce sleep, is neuroprotective, and works as an anti-anxiety compound. The end result is both more deep sleep and REM sleep.

Animal studies also show that it reduces stress and anxiety in rats by reducing stress hormones and increasing GABA. The effects are comparable to anti-anxiety medication.

Lemon balm is included in this anti-anxiety supplement.

16. Passion Flower

Passion Flower represents a family of plants known as Passiflora.

There are about 500 known species of Passion Flower.

One species, Passiflora incarnata, has been shown to reduce anxiety and stress by increasing GABA levels in the brain.

In fact, Passion Flower's role in relation to GABA has been extensively researched (210-212).

Due to its GABA increasing effects, Passion Flower reduces anxiety and certain types of pain.

Passion Flower may also have benefits in some neuropsychiatric disorders, although more human research is needed.

Passion Flower is one of the first herbal remedies I took many years ago to manage my anxiety. It’s included in this anti-anxiety supplement.

17. Yoga

Yoga is a popular “mind-body” relaxation technique that increases the activity of your parasympathetic “rest and digest” nervous system.

Research shows that a single 60-minute yoga session can increase GABA levels in the brain by 27% (81).

Many other studies confirm this outcome and show extremely positive effects on brain GABA levels during and after yoga (82-84).

The researchers also found, not surprisingly, that participants also experienced mood improvements and reductions in anxiety.

These results are even applicable if you struggle with major depressive disorder, as researchers have found that mood can be significantly enhanced (83).

However, even though an increase in GABA can be seen after just one session, studies show that there are bigger and better improvements in GABA levels after a longer period of time. For example, people often see further improvements and higher levels of GABA after going through a 12-week yoga program.

So, for the best results, you will need to maintain the yoga practice over time. In fact, eight days after you stop yoga, the GABA levels in the brain drop back down again. Most of the studies use several yoga sessions per week to get their results.

Lastly, there’s also a strong relationship between GABA levels and activation of the parasympathetic nervous system (84).

The parasympathetic nervous system is often called the “rest and digest” part of the nervous system. The “sympathetic nervous system”, on the contrary, is the “flight and flight” part of the nervous system that’s overactive when you’re very stressed. Yoga supports and activates the parasympathetic nervous system, which then leads to an increase in GABA activity in the brain.

Considering all of this, it’s not too surprising that there’s also a link between practicing yoga and your anxiety levels. Research shows that anxiety levels can drop by 14.7% after just one 2-hour yoga session (85).

Despite all the great research, I’m personally not a big fan of yoga. A lot of people swear by it but it’s just not for me. I prefer meditation and tai chi.

18. GABA Supplements

GABA is not only a signaling compound for the nervous system (neurotransmitter) but you can also supplement with it (92).

Many people claim to experience benefits from taking GABA as a supplement.

Some studies question its effectiveness though. The main reason for questioning that effectiveness is because GABA, as an oral supplement, might not travel from your blood to the brain.

GABA does seem to lower blood pressure, which could then improve brain performance (93).

And ingesting GABA isn’t unnatural. Many foods contain small quantities of the compound (99).

But right now, there’s very limited evidence for using GABA to lower stress levels and increase GABA levels in your brain (94).

And the evidence for using GABA for sleep quality is also insufficient.

I personally don’t recommend taking GABA supplements because in most cases, it simply does not appear to cross the blood-brain barrier.

I have never found any benefits or noticed any effects (positive or negative) from taking GABA supplements. They never reduced my anxiety, and therefore I don’t feel comfortable recommending them.

You’re better off just taking supplements that naturally increase GABA instead of taking GABA supplements directly.

However, there is another related compound called “phenibut” that works and can often help people.

Phenibut is an altered variation of GABA with powerful anti-stress, anti-anxiety, pro-relaxation and pro-sleep quality effects.

Phenibut can travel through the blood to your brain and thus have a very strong effect on sleep quality and anxiety levels (95-98).

The problem with phenibut is that it’s addictive like benzodiazepines and you could experience strong withdrawal effects if you take it regularly and then try to stop it. For this reason, I can’t recommend it.

However, Phenibut is legal in most countries and you can buy it online. If you do decide to use it, you should only use it sparingly during special occasions when you really need to reduce your stress and anxiety, such as before an important nerve-wracking public speaking engagement or presentation.

19. Ashwagandha

Ashwagandha (Withania sominifera) is a popular Indian herb that has been used for more than 3000 years. It’s sometimes called the “Indian Ginseng”.

It’s known as an “adaptogen”, which is a compound that balances the body and restores normal bodily functioning after chronic stress.

It is typically used to inhibit stress and anxiety, but it also affects cognitive function, energy levels, well-being and sleep quality.

It likely has all of these wide-ranging effects because it increases GABA activity and increases GABA levels in the brain (126).

Ashwagandha’s reputation as an adaptogen may be due to the positive effect it has on GABA levels.

As a result of its influence on GABA, ashwagandha might have an effect on many brain disorders, such as epilepsy, anxiety disorders, insomnia, and spasms (126).

Ashwagandha has also long been known as a compound that can improve sleep quality. Both human and animal studies show this. But what the animal studies show is that improvements in GABA function explain the increase in sleep quality. Taking ashwagandha also activates GABA-related genes (128-132).

Ashwagandha is one of the main herbs I took to reduce stress and anxiety as I came off psychiatric medications.

It’s included in the Optimal Calm supplement.

20. Kava

Kava is a plant located in the western Pacific. The root of the plant is used medicinally to treat anxiety and sleep disorders because it causes relaxation without impacting cognitive performance. Some people say it feels like drinking alcohol.

It has been used for centuries to lower stress and anxiety.

One of the mechanisms of kava is that it makes it easier for GABA to bind to its receptors. Kava also inhibits adrenaline (147-151).

Studies also show that kava works similarly to benzodiazepines like Xanax by activating and strengthening GABA receptors in the brain.

Kava is included in a lot of modern research because it can be a compound with fewer side effects than prescription medications with the same goal.

However, kava still has potential side effects, especially skin problems at higher doses. My recommendation is to follow instructions on the product you buy and cycle kava on and off.

I personally don’t take kava anymore because I get a weird reaction from it and I found out I’m allergic to the plant.

21. Bacopa

Bacopa monnieri is a herb that has been used for thousands of years. It’s part of traditional Ayurveda.

It’s commonly used to improve cognition and memory, but it’s also very good at reducing stress.

Animal studies prove that bacopa restores GABA receptors in some parts of the brain (169-172).

As a result, bacopa may have effects on brain conditions such as epilepsy and anxiety.

In humans, bacopa works as a nootropic and may have positive effects for Alzheimer’s and dementia (173).

Many other promising brain effects exist as well, such as increased blood flow in the brain.

In fact, one of the ways bacopa improves cognition is by simply reducing anxiety.

So if you have anxiety, and it negatively impacts your thinking, bacopa is a good choice.

I took a bacopa supplement for a while. I found that it made me really relaxed and sleepy. I eventually stopped taking it because it made me too sleepy. But if you have very severe anxiety, I really think it could be helpful.

22. Lavender

Everyone knows the peaceful and relaxing smell of lavender.

But what you might not know is that breathing the essential oil reduces anxiety and inhibits the glutamate system in the brain.

Animal research also shows that it reduces anxiety in rats by increasing GABA (174-179).

As a result, lavender can significantly increase calmness, relieve restlessness and nervousness, and reduce emotional distress in people with anxiety disorders – without causing any unwanted side effects.

One study found that Silexan, an oral lavender oil capsule, is just as effective at reducing generalized anxiety as lorazepam, a common benzodiazepine. And it didn’t cause side effects or addiction like the anti-anxiety medication.

Lavender can also counter depression and activate your “rest and digest” parasympathetic nervous system.

Lavender essential oil can be taken orally, inhaled or applied to your skin.

23. Chinese Skullcap

Chinese skullcap is a herb that is part of traditional Chinese medicine.

The plant has anti-anxiety properties.

Research shows that it increases GABA activity and binds to GABA receptors within the brain (205-208).

Chinese skullcap can cause potential injuries and side effects from long-term use though, especially in the liver. So make sure to cycle this compound and follow the instructions on the label (209).

24. Black Seed Oil

Nigella sativa, more commonly known as Black Seed Oil, has been used as a natural remedy for more than 2000 years.

It’s surprising more people haven’t heard of it because it’s actually one of the top-ranked evidence-based herbal medicines.

You can use it to increase GABA levels and decrease glutamate in your brain.

Studies show that it significantly reduces anxiety-like behaviour in animals by increasing GABA levels (214-217).

Black seed oil is neuroprotective and has anti-anxiety and sedative effects, in part because of how it influences GABA.

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

Live Optimally,

Jordan Fallis

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References:

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(3) https://pubmed.ncbi.nlm.nih.gov/2573696/

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19 Natural Xanax Alternatives To Reduce Your Anxiety and Stress

October 11, 2024 Jordan Fallis

In today's fast-paced world, feelings of anxiety and overwhelming stress are common.

From sudden bouts of panic to prolonged periods of unease, anxiety affects millions worldwide.

To combat these feelings, many turn to medications like Xanax, a widely prescribed drug that offers temporary relief.

However, while effective, Xanax comes with its own set of side effects.

It also has the potential for dependency, which prompts many to seek more natural solutions.

The allure of natural Xanax alternatives lies in their potential to alleviate anxiety without the accompanying risks of traditional medications like Xanax.

This article will delve into these natural Xanax alternatives, presenting a holistic approach to managing anxiety and stress.

Whether you're someone who's been on Xanax and is seeking a natural substitute, or you're merely curious about holistic health approaches, this guide aims to enlighten and offer choices for a calmer, more balanced state of mind.

Continue reading to learn more.

Why There’s A Growing Need for Natural Xanax Alternatives

Xanax, also known as alprazolam, has undoubtedly provided relief to countless individuals who struggle with anxiety.

This benzodiazepine is known for its rapid onset of action.

It’s very effective at reducing symptoms of anxiety and panic.

But like many prescription medications, it's not without its drawbacks.

For starters, Xanax can present a range of side effects. This includes drowsiness and dizziness, and even more severe issues like respiratory depression and memory problems (1).

Over time, the body can build a tolerance to Xanax, meaning that higher doses may be required to achieve the same therapeutic effects.

This, in turn, leads to physical dependence and addiction, where the body becomes reliant on the drug to function normally.

It's these potential pitfalls of Xanax that lead many to search for alternatives.

Natural solutions can often be gentler on the body and mind, with fewer side effects. They can also promote overall well-being instead of just simply suppressing symptoms.

Plus, natural remedies often encompass broader lifestyle changes. This empowers individuals to take control of their mental health in diverse ways, from dietary shifts to mindfulness practices.

In a society increasingly leaning towards organic, chemical-free, and holistic approaches to well-being, interest in natural Xanax alternatives is both understandable and timely.

In the next sections, I’ll explore these natural Xanax alternatives in depth.

The Best Plant and Herbal Alternatives to Xanax

1. Passion Flower

Passion flower is scientifically known as Passiflora incarnata.

It’s been used for centuries as a remedy for various ailments, mainly for its calming and sedative properties.

As a result, it presents a promising natural alternative to pharmaceutical drugs like Xanax.

Passion flower contains compounds that have sedative properties, which can help reduce anxiety.

It's believed to increase levels of gamma-aminobutyric acid (GABA) in the brain. GABA lowers the activity of some brain cells, promoting a sense of relaxation (2).

Several studies have explored the effectiveness of passionflower in treating anxiety.

In one study, researchers found that it can be just as effective as benzodiazepine drugs for generalized anxiety disorder (GAD) (3).

Another showed that it can reduce pre-surgery anxiety, comparable to standard medications (4).

Passion flower can be consumed in various forms, including teas, tinctures, capsules and liquid extracts.

I personally have experience with Passion flower. It was one of the first herbal remedies I took many years ago to manage my anxiety. That’s why it’s included in this anti-anxiety supplement.

Passion flower can be safely combined with other natural anti-anxiety remedies, amplifying its effects.

For instance, combining it with lemon balm or valerian root can provide a more potent calming effect.

2. Valerian

natural-xanax-alternatives-over-the-counter-remedies-supplements-elderly-similar-non-addictive-prescription-safe-tea-fast-acting-anxiety-without-medication-drugs-substitute-herbal-relief-stress-natural-organic-holistic-replacements-pills-side-effects

Valerian root is a natural remedy and medicinal herb, derived from the Valeriana officinalis plant.

It has been used for thousands of years to treat various conditions.

Its most celebrated use is for sleep disorders and anxiety.

As a result, Valerian root is an attractive natural sedative and compelling alternative to drugs like Xanax.

In fact, it’s often called “Nature’s Valium”.

Numerous studies have delved into Valerian's effectiveness for anxiety.

Researchers have found that Valerian reduces the physiological symptoms of anxiety, such as palpitations and trembling (6).

Valerian is available in various preparations, including teas, tinctures, capsules, and tablets.

Along with Passion flower, Valerian was one of the first herbal remedies I took many years ago to manage my anxiety. I would take it at night to reduce anxiety and improve my sleep. It’s included in this anti-anxiety supplement.

Valerian can be combined with other natural remedies, such as lemon balm, to create synergistic effects, making it more potent than using it on its own.

3. Lemon Balm

Lemon balm, with its botanical name Melissa officinalis, is a perennial herb from the mint family.

Its gentle lemon scent has made it popular in culinary dishes.

But beyond its aromatic allure, lemon balm has a longstanding reputation in herbal medicine.

It’s particularly known for its calming properties.

Research indicates that lemon balm can elevate mood, ease nervousness, and counteract anxiety-related stress (9).

Much like Valerian and Passion flower, lemon balm is believed to positively influence GABA levels in the brain. As a result, it promotes relaxation and reduces overactivity in the nervous system (10).

Scientific studies on lemon balm have showcased its benefits for anxiety.

One particular study revealed that participants who consumed lemon balm reported improved mood and significantly reduced levels of anxiety (11).

Lemon balm also contains compounds like rosmarinic acid, which possess neuroprotective properties (7-8).

As a result, it can also improve cognitive performance and increase alertness (12).

This makes it unique, as it calms the mind without causing drowsiness, a common side effect of many anti-anxiety medications.

Lemon balm works well in conjunction with other herbs.

For instance, when paired with Valerian root, the combination can be particularly effective in treating insomnia and restlessness.

Lemon balm is included in this anti-anxiety supplement.

Beyond supplements and teas, lemon balm is also used in essential oil form for aromatherapy.

4. Lavender

Lavender, renowned for its signature scent and stunning purple hue, belongs to the Lavandula genus.

It’s been a staple in traditional medicine for centuries.

Today, lavender stands out as a promising natural Xanax alternative.

Multiple studies have revealed that lavender oil can effectively reduce generalized anxiety (13).

In some research, the anxiety-reducing effects of lavender were found to be comparable to anti-anxiety medications (14).

Silexan is a standardized lavender oil preparation available in oral capsule form.

Clinical trials have shown that Silexan is effective at reducing anxiety. It even compares favorably to some conventional benzodiazepines and antidepressants, but without the potential for addiction or significant drowsiness (15).

One of the most popular uses of lavender is in aromatherapy.

Inhaling lavender essential oil has been linked to reduced stress and anxiety, and even improved sleep (16).

This method offers immediate relief, especially in acute stress situations.

Some studies suggest that lavender can also enhance cognitive function, especially in high-stress situations. This positions it uniquely, as it offers both relaxation and mental clarity (17).

Preliminary research suggests that lavender might have antidepressant properties as well (18).

Beyond its oral and aromatic applications, lavender can be incorporated into massages, baths, or even as a topical solution.

5. Kava

Kava is derived from the roots of the Piper methysticum plant, found in the South Pacific islands.

It has a history deeply embedded in cultural rituals and traditional medicine.

Its consumption typically results in a calming effect.

This makes it a popular natural remedy for anxiety and a contender to medications like Xanax.

The primary active compounds in Kava are kavalactones, which are believed to affect neurotransmitters in the brain, particularly GABA and dopamine (19).

This influence can lead to feelings of calmness, relaxation, and euphoria.

Multiple clinical studies have investigated the effectiveness of Kava in treating anxiety.

A systematic review of these studies indicated that Kava is a beneficial and effective treatment for anxiety. The researchers concluded it has positive effects similar to the effects of standard anti-anxiety medications (20-22).

Kava is known to produce quick results, with many users reporting anxiety-reducing effects within an hour or even minutes of consumption. This rapid action can be especially helpful in acute anxiety situations.

However, kava still has the potential for side effects, especially skin problems at higher doses. My recommendation is to follow the instructions on the product that you buy and cycle kava on and off.

I personally don’t take kava anymore because I get a weird reaction from it and I found out I’m allergic to the plant.

6. Ashwagandha

Ashwagandha, also known as Withania somnifera, is a herb used in Ayurvedic medicine, an ancient Indian system of natural healing.

Often called the "Indian ginseng," this adaptogenic herb has been used for over 3,000 years to relieve stress, increase energy levels, and improve concentration.

Many people today are turning to Ashwagandha as a natural alternative to pharmaceuticals like Xanax.

Clinical trials have found that Ashwagandha can effectively reduce stress and anxiety (23).

In some studies, the reduction in anxiety with Ashwagandha supplementation rivalled those achieved by some psychiatric drugs (24).

One of the primary ways Ashwagandha combats stress and anxiety is by regulating cortisol levels. Cortisol is the body's primary stress hormone. Elevated cortisol, especially chronically, can lead to a myriad of health issues, including increased anxiety.

Studies have shown that Ashwagandha can significantly reduce cortisol levels (25).

Ashwagandha also possesses neuroprotective characteristics, supporting brain health, enhancing mood, and reducing the risk of neurodegenerative diseases (26).

Ashwagandha is one of the main herbs I took to reduce stress and anxiety as I came off my psychiatric medications.

It’s included in the Optimal Calm supplement.

7. Chamomile

Chamomile is an age-old herbal remedy.

It’s commonly recognized as a soothing tea ingredient.

But beyond its comforting aroma and flavor, chamomile holds therapeutic properties.

As a result, it has been a staple in traditional medicine across various cultures, and it’s a potential alternative to pharmaceuticals like Xanax.

Chamomile contains apigenin, which is an antioxidant that binds to certain receptors in the brain, which then promotes relaxation and reduces insomnia. Its mild sedative effect is one reason why chamomile tea is a popular bedtime drink (27).

Studies have shown that chamomile extract can help reduce symptoms of generalized anxiety disorder (GAD) (28).

Some participants in these studies experienced a reduction in anxiety comparable to certain psychiatric drugs (29).

Along with its anxiety-reducing properties, chamomile also exhibits antidepressant activity (30).

Lastly, chronic inflammation is often linked to anxiety and mood disorders, and chamomile's potent anti-inflammatory properties can help counteract this (31).

Beyond teas, chamomile is available in various forms, including supplements, essential oils, and topical applications.

The Best Supplements and Nutrient Alternatives to Xanax

8. Magnesium

Magnesium is an essential mineral that’s required for over 300 enzymatic reactions in the body.

Its importance in supporting brain function makes it a notable natural Xanax alternative for managing anxiety.

Magnesium plays a critical role in the proper functioning of the nervous system.

By modulating the activity of NMDA receptors in the brain, magnesium can help regulate neural excitability, preventing overstimulation and promoting calmness (32).

Chronic stress can deplete magnesium levels in the body (33).

Conversely, adequate magnesium levels can help regulate the body's stress-response system (34).

Magnesium is also involved in the synthesis of neurotransmitters like GABA, which are crucial for the regulation of anxiety and mood (35).

Many individuals, especially in the Western world, are magnesium-deficient and would benefit from supplementation.

Magnesium is included in this supplement.

Magnesium works even better with vitamin B6.

Research shows that combining magnesium with vitamin B6 can enhance the absorption and effectiveness of magnesium. And some studies suggest this combination can be particularly effective in alleviating anxiety (36-37).

You should also make sure you’re eating magnesium-rich foods on a regular basis, including:

Spinach
Chard
Pumpkin seeds
Almonds
Avocado
Dark chocolate
Bananas

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

Lastly, you can also increase your body’s intake of magnesium by taking Epsom salt baths.

9. Theanine

Theanine is an amino acid predominantly found in tea leaves (especially green tea).

It’s one of the reasons why tea gives you a very relaxed and less stimulating experience than coffee.

Theanine has gained attention for its calming and cognitive-enhancing properties. As a result, it’s a compelling natural option for those seeking relief from stress and anxiety.

Theanine has been shown to increase the production of alpha brain waves, which are associated with states of relaxed alertness. By promoting this brain wave activity, it can help ease the mind without causing drowsiness (38).

Theanine also increases the production of certain neurotransmitters, such as dopamine, serotonin, and GABA. These neurotransmitters play a pivotal role in relaxation, mood regulation, and overall brain function (39).

Studies have indicated that theanine can also help reduce the physiological responses to stress. Individuals taking theanine experience a reduction in heart rate and salivary immunoglobulin A, both of which typically spike during stress (40-41).

Beyond its calming effects, theanine has been associated with improved focus, alertness, and cognitive performance, especially when taken in combination with caffeine.

If you’re interested in supplementing with theanine, this anti-anxiety supplement contains it.

10. Omega-3 Fatty Acids

Omega-3 fatty acids include EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

They are vital nutrients with an impressive array of health benefits.

Many studies show that they significantly reduce brain inflammation; improve memory, mood and cognition; and protect against mild cognitive impairment, dementia and Alzheimer's disease.

They also play a key role in mood regulation and the alleviation of anxiety.

Multiple studies have indicated that individuals with higher omega-3 intake or higher blood levels of omega-3s tend to have reduced symptoms of anxiety (42).

Clinical trials have also shown promise in using omega-3 supplements to alleviate anxiety (43).

Some studies suggest that omega-3 supplementation can reduce cortisol (a primary stress hormone) in response to stressful situations (44).

Omega-3s also influence the release and function of neurotransmitters such as serotonin and dopamine, which are both essential for optimal mental health (45).

As you may know, chronic inflammation has been linked to mood disorders, including anxiety.

Omega-3s, especially EPA, exhibit potent anti-inflammatory effects, which can then benefit brain health and alleviate symptoms of anxiety (46).

Omega-3s also play a protective role against the onset of anxiety and depression, particularly when consumed in adequate amounts from an early age (47).

Omega-3 fatty acids are considered “essential fatty acids”, meaning your body cannot create them. You have to get them from food or supplements.

Food sources of omega-3 fatty acids include:

Fatty fish like salmon, mackerel, and sardines
Flaxseeds
Chia seeds
Walnuts
Eggs

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

Supplements, like fish oil, are also commonly used to increase omega-3 intake.

11. B Vitamins

B vitamins are a group of water-soluble vitamins that are essential for optimal health.

They have long been recognized for their role in maintaining nerve function, supporting metabolism, and aiding cellular processes.

As research progresses, there's growing evidence linking adequate B vitamin intake with improved mood and reduced anxiety.

While they don't directly replace medications like Xanax, B vitamins can be an instrumental part of a holistic approach to mental health.

The nervous system relies heavily on B vitamins, especially B1 (thiamine), B3 (niacin), and B12, for its proper function. Deficiencies can lead to symptoms such as anxiety (48).

Certain B vitamins, notably vitamin B6 (pyridoxine), are involved in the synthesis of neurotransmitters such as serotonin, dopamine, and GABA. All of these neurotransmitters play a crucial role in mood regulation and anxiety control (49).

The adrenal glands, responsible for releasing stress hormones, require adequate amounts of vitamin B5 (pantothenic acid) for proper function. Maintaining optimal adrenal health by supplementing with Vitamin B5 can help in managing the body's stress response (50).

B vitamins can be found in a variety of foods. Meats, seeds, nuts, and dark leafy greens are all excellent sources.

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

B vitamins are also included in the Optimal Calm supplement.

12. Probiotics

Probiotics are beneficial bacteria and yeasts. They have historically been lauded for their role in digestive health.

But recent scientific advances have discovered a fascinating connection between your gut microbiome and your brain, often referred to as the "gut-brain axis."

The gut and the brain communicate through multiple pathways, including the vagus nerve, neurotransmitters, and the immune system (51-53).

This bi-directional communication means that the state of your gut can influence your mental health.

Many neurotransmitters are predominantly produced in the gut. As a result, probiotics can influence the production and modulation of these neurotransmitters (54).

An imbalanced gut can also lead to chronic inflammation, which is increasingly linked to various mood disorders, including anxiety.

Probiotics can help restore balance to the gut microbiome, reducing inflammation and its detrimental effects on your mental health (55).

Some studies even suggest that individuals with a balanced gut microbiome have a healthier physiological response to stress, which includes a more regulated cortisol (stress hormone) response (56).

Multiple clinical trials have investigated the effects of specific probiotic strains on mood and anxiety. Researchers have found that certain strains can alleviate anxiety and improve overall mood (57).

Lastly, a balanced gut can more efficiently absorb essential nutrients, including those vital for brain function and mental health, such as B vitamins, magnesium, and omega-3 fatty acids (58).

Fermented foods like yogurt, kefir, sauerkraut, kimchi, miso, and tempeh are rich natural sources of probiotics. Incorporating these foods into your diet can support a balanced gut microbiome.

You can also take a probiotic supplement, such as Optimal Biotics.

Check out this article for several other ways to increase the good bacteria in your gut.

And if you struggle with anxiety, here are 9 probiotic strains that can help.

The Best Lifestyle Alternatives to Xanax

13. Meditation

The ancient practice of meditation, deeply rooted in numerous cultures and traditions, has stood the test of time.

With modern scientific methodologies, we're now beginning to understand its profound beneficial effects and its ability to reduce stress and anxiety.

While meditation is not a direct pharmaceutical alternative like Xanax, consistent meditative practice offers meaningful benefits.

Neuroimaging studies have shown that consistent meditation can lead to changes in the structure and function of the brain.

During a meditation session, areas of the brain associated with stress and anxiety show reduced activity (59).

Regular meditation practice can also bolster the parasympathetic (or "rest and digest") nervous system, promoting relaxation and counteracting the effects of the stress-induced "fight or flight" response (60).

Research shows that being in the present moment can reduce rumination (repetitive thinking about the past) and excessive worry about the future (61).

Meditation can also stimulate the production of neurotransmitters like serotonin, dopamine, and endorphins, all of which play roles in the mitigation of anxiety (62).

For best results, you should aim for at least 10-20 minutes of meditation per day.

If you're new to meditation, start with just a few minutes each day and then gradually increase the time as you become more comfortable with the practice.

And remember, consistency is key. Like physical exercise, the benefits of meditation are often most pronounced with regular and consistent practice.

There are various forms of meditation, including mindfulness-based stress reduction (MBSR), transcendental meditation, and loving-kindness meditation. It can take some exploration to find which method resonates with you.

Meditation is personally one of my favorite daily activities to maintain optimal brain function and mental health.

I personally use and recommend the Muse headband to meditate. It gives you real-time feedback while you meditate. It makes meditation a lot more fun and tolerable.

I previously wrote about it here, and you can get it through the Muse website.

14. Deep Breathing

Breathing, a fundamental life process, often goes unnoticed.

Yet, the manner in which we breathe can greatly influence our physiological and psychological state.

Deep breathing exercises, sometimes referred to as diaphragmatic or abdominal breathing, have been practiced across various cultures and traditions as a method to calm the mind.

While they're not an exact substitute for medications like Xanax, they can still be a potent tool in managing your anxiety and stress.

Shallow or rapid breathing is a typical response during stressful situations, activating the sympathetic ("fight or flight") nervous system.

Deep breathing exercises, on the other hand, stimulate the parasympathetic nervous system, which counteracts stress and promotes relaxation (63).

Concentrating on your breath can bring attention to the present moment, reducing ruminative thoughts about the past or worries about the future.

Deep breathing also lowers levels of cortisol, the primary stress hormone in the body, which then leads to reduced anxiety (64).

Lastly, breathing exercises can stimulate the release of endorphins, leading to feelings of relaxation (65).

Initially, it might feel unnatural or even challenging to breathe deeply, especially if you’re used to shallow breathing. But regular practice can help in making deep breathing a more spontaneous response to stress.

There are various deep breathing techniques, such as the 4-7-8 method (inhale for 4 seconds, hold for 7, exhale for 8), box breathing, and paced respiration. You’ll need to experiment to find which technique works best for you.

For beginners, guided deep breathing sessions, available through apps or online videos, can also be helpful.

The best way to know if you’re on the right track is by using the EmWave2 device. It’s a biofeedback device that assists you in pacing your breathing. I previously wrote about the benefits of using the device here. You can get it through the HeartMath website.

15. Yoga

As the popularity of yoga has spread globally, scientific studies have begun to validate its effectiveness as a tool for optimal mental health.

While yoga isn't a direct pharmaceutical counterpart to Xanax, its consistent practice can substantially aid in managing anxiety and stress.

Many yoga practices activate the parasympathetic nervous system, which is responsible for relaxation and recovery. This counteracts the "fight or flight" stress response driven by the sympathetic nervous system (66).

Yoga also stimulates the production of endorphins, which can lead to a reduction in stress and anxiety (67).

There are many styles of yoga. Depending on your needs and preferences, it might take some time to find the most suitable style for you.

While many find anxiety relief through yoga, it might not resonate with everyone.

Despite all the great research behind yoga, I’m personally not a big fan of it. A lot of people swear by it but it’s just not for me. I prefer meditation and tai chi.

16. Tai Chi

Originating in ancient China, Tai Chi is often described as "meditation in motion."

It embodies a form of martial art and includes a series of gentle physical exercises and stretches.

While Tai Chi does not function as a direct replacement for medications like Xanax, its integration of movement and mindfulness offers substantial benefits for those grappling with anxiety and stress.

Regular practice of Tai Chi has been shown to reduce levels of the stress hormone cortisol. As a result, individuals can experience decreased feelings of stress and anxiety (68).

For beginners, it's beneficial to learn Tai Chi under the guidance of a qualified instructor. This ensures proper form and maximizes the benefits.

Just like any practice, the benefits of Tai Chi are best realized with regular and consistent practice.

17. Exercise

Exercise is a universal remedy with a myriad of benefits for both the body and the mind.

Its ability to alleviate anxiety and stress is backed by a wealth of scientific evidence, and it’s an attractive natural alternative to medications like Xanax.

Regular exercise can help regulate and reduce the release of cortisol, the primary stress hormone, promoting a more balanced emotional state (69).

Engaging in physical activity stimulates the release of endorphins, which foster a sense of wellbeing (70).

Physical activity can also help regulate the autonomic nervous system. A balanced autonomic nervous system means there’s a healthy balance between the sympathetic (fight or flight) and parasympathetic (rest and digest) responses (71).

The best type of exercise is one that you’ll enjoy and stick with. Whether it’s walking, jogging, cycling, swimming, dancing, or weightlifting, personal preference plays a crucial role in adherence.

Exercise also increases nerve-growth factor, orexin, GABA, GDNF, and reduces inflammation in the brain.

Not surprisingly, exercise is recommended by many experts as their number one piece of advice for optimal brain function and mental health.

18. Limit Caffeine

Caffeine is commonly found in coffee, tea, energy drinks, and certain medications.

It is a central nervous system stimulant that affects millions of people daily.

Cutting back or eliminating caffeine can serve as a natural approach to reducing anxiety, making it a lifestyle alternative to medications like Xanax.

While many people love that caffeine makes them more alert and energetic, caffeine also exacerbates symptoms of anxiety, such as feelings of nervousness, restlessness, and increased heart rate (72).

For those prone to panic attacks, excessive caffeine can trigger these episodes or intensify their severity due to its excitatory effects on the nervous system (73).

Keep in mind that individuals metabolize caffeine at different rates and have varying thresholds for its effects. Some people might be particularly sensitive to caffeine and experience heightened anxiety even with small amounts.

However, it’s important to point out that coffee is definitely good for brain function. There is a lot of research showing it is very healthy and can be protective against dementia.

I used to not be able to handle any coffee at all. But now that I'm healthy, I can handle it just fine. I drink one cup of high-quality coffee most mornings.

But if you’re struggling with chronic stress and anxiety, I wouldn’t recommend high doses of caffeine.

My recommendation is to limit your caffeine intake, have caffeine-free days, and/or stop caffeine consumption several hours before bedtime to prevent potential sleep disruptions.

An alternative solution is to consume the whole coffee fruit, instead of drinking coffee.

Concentrated coffee fruit extract doesn’t contain caffeine, but it does contain several healthy compounds not found in coffee beans themselves.

Scientists have discovered that ingesting whole coffee fruit concentrate significantly increases brain function.

Coffee fruit concentrate can be found in the Optimal Brain supplement.

19. Limit Alcohol

Alcohol is often viewed as a social lubricant, a means to relax, or even a temporary escape from the stresses of life.

While it might offer short-term relief from anxiety for some individuals, the long-term relationship between alcohol and anxiety is more complicated.

In many instances, limiting or abstaining from alcohol can be a constructive step towards managing anxiety, presenting itself as a natural lifestyle alternative to medications like Xanax.

While alcohol can induce feelings of relaxation and euphoria initially, as its effects wear off, it can lead to increased heart rate, dehydration, and a surge in stress hormones, which can amplify feelings of anxiety (74).

Alcohol alters levels of neurotransmitters in the brain, including serotonin and GABA. These imbalances can then result in increased anxiety levels later (75).

Alcohol also disrupts the blood-brain barrier, and increases inflammation and oxidative stress in the brain.

There are ways to protect your brain from alcohol, but you’re better off avoiding it completely or significantly reducing your consumption if you’re trying to reduce anxiety. I personally don’t drink alcohol at all anymore. It’s just not worth it.

If you do decide to drink it, this post explains that some types of alcohol are better than others.

The Benefits of Natural Alternatives to Xanax

Natural remedies for anxiety and stress have been employed for centuries across various cultures, each with its own set of plant-based remedies, relaxation techniques, and holistic philosophies.

As modern medicine evolves, it has begun to embrace, study, and confirm the benefits of some of these age-old practices.

Here are some prominent advantages of the natural alternatives I listed above:

Fewer Side Effects: One of the most significant draws towards natural remedies is the reduced risk of side effects. Unlike psychiatric drugs, which can sometimes cause drowsiness, dependency, or other adverse reactions, natural alternatives are typically gentler on the body.

Support Overall Wellbeing: Natural remedies often go beyond just treating a specific symptom. They can enhance overall health by promoting better sleep, improved digestion, and bolstered immunity. For instance, herbs like Ashwagandha not only reduce anxiety but also help balance hormones and boost immune function.

Synergistic Effects: Some natural treatments, especially when combined, can have a synergistic effect, meaning the combined impact is greater than the sum of their individual effects. For instance, combining meditation with a balanced diet can lead to better mental clarity and reduced anxiety than either approach alone.

Sustainable & Preventative: Natural alternatives can be part of a long-term strategy to manage and even prevent anxiety. By incorporating habits like regular exercise or mindfulness practices, individuals can build resilience against future stressors.

Empowerment & Autonomy: Taking a proactive stance by using natural remedies can lead to a sense of empowerment. It fosters a mindset of active participation in one's healing journey, creating a deeper connection between mind and body.

Holistic Approach: Natural methods often look at the body as a whole interconnected system, addressing the root causes of anxiety instead of merely suppressing the symptoms. This holistic perspective ensures that the underlying issues are addressed, leading to more profound and lasting relief.

Flexibility & Personalization: The plethora of natural remedies available means individuals can tailor their approach to fit their unique needs and preferences. This flexibility can lead to more effective and personalized treatments.

In summary, natural alternatives offer a multifaceted approach to handling anxiety and stress.

While they may not replace traditional treatments in every scenario, they provide valuable tools that can either complement conventional therapies or serve as primary methods of care for those seeking a more organic route to mental and emotional equilibrium.

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

Live Optimally,

Jordan Fallis

Connect with me

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32 Proven Ways to Increase Nerve Growth Factor (NGF)

June 20, 2024 Jordan Fallis

Nerve Growth Factor (NGF) plays a crucial role in keeping your mind sharp.

It’s a protein that supports the growth, survival, and maintenance of nerve cells.

It's absolutely essential for optimal cognitive performance.

But with age, stress, and various lifestyle factors, NGF levels can decline over time.

This can lead to reduced mental sharpness and an increased risk of neurodegenerative disorders.

Fortunately, there are many science-backed ways to boost your NGF levels.

In this article, I'll delve into the fascinating world of NGF.

I’ll explore the importance of NGF for optimal brain function.

And then I’ll provide some actionable strategies to enhance NGF production naturally.

Read on as I uncover the importance of NGF and share 32 proven methods to increase its production.

By implementing these strategies, you'll be well on your way to achieving optimal brain function and unlocking the full potential of your mind.

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What Is Nerve Growth Factor (NGF)?

Nerve Growth Factor (NGF) is a protein that belongs to a family of molecules called neurotrophins.

Neurotrophins are essential for the development and maintenance of neurons. Neurons are the primary cells responsible for transmitting information within the nervous system.

NGF was the very first neurotrophin discovered by scientists. It was discovered in the 1950s by Rita Levi-Montalcini and Stanley Cohen. They later received the Nobel Prize for their work.

NGF has since been the subject of extensive research due to its crucial role in neuronal health.

NGF is primarily involved in the growth, survival, and maintenance of nerve cells, particularly those responsible for transmitting pain, temperature, and touch sensations.

It promotes the survival of existing neurons, helps with the growth of new neurons (neurogenesis), and assists in repairing damaged nerve cells.

NGF also plays a significant role in the formation and preservation of synapses. Synapses are the junctions between neurons that enable communication within the brain. NGF’s impact on synapses makes it absolutely critical for learning, memory, and overall cognitive performance.

The Benefits of Increasing NGF Levels and How It Affects Your Brain

NGF has a positive impact on various aspects of brain health and cognitive function.

Increasing your NGF levels can be the key to unlocking a healthier, more vibrant brain.

Some of the key benefits of boosting NGF include:

Enhanced cognitive function: Higher NGF levels can support the growth and survival of neurons, leading to enhanced cognitive abilities, such as improved memory, learning, and problem-solving (1-3).

Support for nerve regeneration: Increased NGF levels can support the regeneration of nerves, which can be particularly beneficial in cases of nerve injury or damage (4-5).

Enhanced neuroplasticity: Higher NGF levels also contribute to improved synaptic plasticity, which is the brain's ability to adapt and reorganize its connections in response to new experiences and learning. Increasing NGF levels can promote more efficient neural connections and improve the brain's adaptability (6-7).

Better mood and reduced anxiety: NGF has been found to play a role in mood regulation, particularly in the production and function of serotonin and other neurotransmitters. As a result, increasing NGF has been associated with improved mood, reduced anxiety and depression, and overall emotional well-being (8-10).

Neuroprotection and protection against neurodegenerative diseases: Having adequate NGF levels can help protect neurons from damage. As a result, increasing NGF can reduce the risk of age-related cognitive decline and neurodegenerative disorders like Alzheimer's disease and Parkinson's disease (11-14).

Support for brain injury recovery: NGF plays a role in nerve repair and regeneration, making it a potential therapeutic target for recovering from brain injuries and strokes (15-16).

Pain relief: NGF plays a role in pain perception and regulation. Increased NGF levels can help alleviate chronic pain in certain conditions, such as neuropathic pain (17-20).

Improved stress resilience: Higher NGF levels may help the brain better cope with stress and recover from stress-related damage, leading to improved stress resilience and overall mental health (21-23).

Conditions and Symptoms Associated with Low NGF Levels

Low levels of Nerve Growth Factor (NGF) have been linked to various health conditions, particularly those related to the nervous system and cognitive function.

Some health conditions that have been linked to low NGF levels include:

Alzheimer's disease: Lower NGF levels have been observed in patients with Alzheimer's disease. Insufficient NGF can contribute to the degeneration of cholinergic neurons, which play a critical role in cognitive function (24-27).

Parkinson's disease: Reduced NGF levels have also been reported in Parkinson's disease, a neurodegenerative disorder that affects movement and motor function (28-30).

Depression and anxiety: Low NGF levels have been associated with mood disorders such as depression and anxiety. NGF is involved in the regulation of neurotransmitters like serotonin, which plays a role in mood regulation (31-32).

Schizophrenia: Some studies have found lower NGF levels in individuals with schizophrenia, a complex mental disorder that affects thinking, perception, and behavior (33-34).

Chronic pain: NGF is involved in pain perception and regulation, and low NGF levels may contribute to the development or maintenance of chronic pain conditions, such as neuropathic pain or fibromyalgia (35-38).

Age-related cognitive decline: Reduced NGF levels may contribute to age-related cognitive decline and the development of age-related neurodegenerative disorders (39-40).

Multiple sclerosis: Some studies suggest that low NGF levels may be associated with multiple sclerosis, an autoimmune disease that affects the central nervous system (41-43).

Autism spectrum disorder: Some studies have suggested that low NGF levels may be associated with autism spectrum disorder (ASD), a developmental disorder that affects communication and behavior (44-46).

Obsessive-compulsive disorder (OCD): Preliminary research has suggested a possible link between low NGF levels and OCD, a mental health disorder characterized by recurring, unwanted thoughts and compulsive behaviors (47).

Traumatic brain injury (TBI): Reduced NGF levels have been observed in individuals who have experienced a TBI. Adequate NGF levels may play a role in neuronal repair and recovery following brain injury (48).

Now, let’s dive into how to increase your NGF levels.

The Best Lifestyle Habits, Therapies and Practices To Increase NGF

1. Exercise

Exercise not only helps improve cardiovascular health and general well-being.

It also has direct benefits on cognitive function and neuroplasticity.

Regular physical activity has been shown to have a significant impact on brain health, including increasing NGF levels.

Studies have shown that regular aerobic exercise can enhance memory and learning by increasing NGF levels in the brain (83).

Activities like running, swimming, cycling, or brisk walking increase heart rate and blood flow, promoting the release of various growth factors, including NGF (84).

Strength training exercises, such as weightlifting or bodyweight exercises like push-ups and squats, have also been associated with increased NGF levels (85).

By including a combination of aerobic exercise and resistance training in your routine, you can effectively increase NGF levels and promote better cognitive function, memory, and learning.

Regular exercise also helps reduce stress and improve mood.

Exercise is recommended by many experts and it’s often their number one piece of advice for optimal brain health.

My usual advice is to find a sport or exercise routine that you enjoy, so that you’ll stick with it consistently.

2. Sleep

Sleep plays a vital role in maintaining brain health and function, including the regulation of NGF levels.

During sleep, the brain undergoes essential processes such as memory consolidation, toxin clearance, and neural repair.

All of these processes are influenced by NGF.

Research has shown that NGF levels naturally fluctuate throughout the day, with higher levels occurring during nighttime sleep (87).

This increase in NGF during sleep is believed to support the brain's restorative processes and facilitate memory consolidation.

Moreover, sleep deprivation has been shown to negatively impact NGF levels. This then leads to impaired cognitive function, reduced memory, and increased susceptibility to stress (86).

This suggests that getting adequate sleep is crucial for maintaining optimal NGF levels and overall brain health.

I personally used to have very poor sleep and it was one of the main factors that contributed to my poor cognitive function.

If you’re having trouble with sleep, try this sleep supplement. It contains magnesium and other natural compounds that I’ve used over the years to promote deeper and more restful sleep.

I also work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have a free online workshop that talks about how you can work with us. You can register for the workshop here.

3. Meditation

Meditation is a practice that involves focusing the mind, promoting relaxation, and developing a heightened state of awareness.

Regular meditation has been shown to have numerous benefits for mental well-being.

The benefits include stress reduction, improved concentration, and increased self-awareness.

In addition to these benefits, meditation has also been found to positively influence NGF levels.

Research suggests that meditation can increase the production of NGF in the brain, particularly in areas related to learning, memory, and emotional regulation (88).

This increase in NGF levels may be one of the mechanisms through which meditation supports cognitive function and overall brain health.

Studies have also shown that meditation can help reduce stress and inflammation, both of which can negatively impact NGF levels (89-91).

To experience the benefits of meditation on NGF levels and brain health, it's essential to practice regularly.

You should aim for at least 10-20 minutes of meditation per day, gradually increasing the duration as you become more comfortable with the practice.

By incorporating meditation into your daily routine, you can effectively support NGF production, improve cognitive function, and promote overall mental well-being.

Meditation is one of my favorite daily activities and treatments to maintain optimal brain function and mental health.

I recommend the Muse headband to meditate. It gives you real-time feedback while you meditate. It makes meditation a lot more fun and tolerable.

I previously wrote about it here, and you can get it through the Muse website.

4. Sunlight (Vitamin D)

Exposure to natural sunlight is crucial for the production of vitamin D in the skin.

Vitamin D is involved in various neurophysiological processes, including neuroprotection, neuroplasticity, and neurotransmitter synthesis.

It also plays a role in the regulation of nerve growth factor (NGF).

Low levels of vitamin D have been associated with an increased risk of developing neurological and psychiatric disorders.

But studies show that higher levels of vitamin D can support NGF production and increase NGF levels in the brain.

In a review article, researchers highlight the role of vitamin D in the nervous system, including its impact on neurotrophic factors such as NGF.

The authors discuss how vitamin D has been shown to promote the synthesis of NGF (92).

Another review article discusses the potential role of vitamin D in various neurological diseases.

The authors mention that vitamin D deficiency has been associated with decreased NGF production (93).

Besides sunlight exposure, fatty fish and dairy products are some food sources of vitamin D.

But vitamin D supplementation is often necessary for those with limited sun exposure or dietary restrictions.

If you have limited sun exposure or dietary sources, you should consider taking a vitamin D supplement to boost your NGF levels and support your brain health.

Sunlight exposure is definitely better than supplements, though.

I personally get sunlight every single day during the spring and summer months.

It’s important to get the sunlight in your eyes to trigger the release of neurotransmitters. So make sure you don’t wear contacts, glasses or sunglasses when you go outside. It’s especially important to do this in the morning because it sets your circadian rhythm.

At the very least, you should take a Vitamin D supplement if you’re deficient. I take some Vitamin D3 in supplement form, depending on my levels.

But it's important to test and monitor your Vitamin D levels before and after supplementing with it.

5. Low-Level Laser/Light Therapy (LLLT)

Low-level laser/light therapy (LLLT), also known as photobiomodulation, uses light at specific wavelengths to modulate cellular activity.

It has been shown to have various therapeutic effects on the nervous system.

There is a narrative review that summarizes the current knowledge on the therapeutic effects of LLLT in various neurological conditions.

In the review, the authors discuss the potential mechanisms of action of LLLT.

They talk about how it can upregulate neurotrophic factors such as NGF, and this then contributes to the overall benefits observed in nervous system disorders (96).

Some studies have looked at the direct impact of LLLT on NGF levels.

In one study, researchers investigated the effects of LLLT on spinal cord injury.

The researchers found that LLLT significantly increased levels of NGF.

They concluded that LLLT can promote nerve regeneration and functional recovery by increasing NGF (94).

Another study looked at the efficacy of LLLT on peripheral nerve regeneration following nerve injury.

The authors again found that LLLT significantly increased NGF levels, and it contributed to improved nerve regeneration and functional recovery (95).

I previously wrote about my experience with LLLT here.

I use this device and shine the red and infrared light on my forehead for 5 minutes every day. I also shine it on other parts of my head and on my entire body, including on my thyroid, thymus gland and gut. I experience incredible benefits from doing this.

When I’m traveling, I take this smaller and more convenient device with me and shine it on my forehead.

I’ve also been using the Vielight Neuro Duo, which is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to try a Vielight device, you can use the coupon code JORDANFALLIS for a 10% discount.

Before trying LLLT, I highly recommend reading my full article about it first.

6. Cognitive Stimulation

Cognitive stimulation involves engaging in various mental exercises and activities to enhance cognitive function.

Mentally stimulating activities include puzzles, reading, learning a new language, or playing a musical instrument.

Research suggests that cognitive stimulation can boost NGF levels.

In a review article, researchers discuss the effects of environmental enrichment and cognitive stimulation on brain function and plasticity.

The authors highlight that these interventions can lead to the upregulation of neurotrophic factors such as NGF (99).

In another review article, researchers discuss the benefits of cognitive stimulation on brain health and plasticity.

The authors propose that one potential mechanism by which cognitive stimulation exerts its effects is through the upregulation of neurotrophic factors such as NGF (97).

In one study, the researchers found that cognitive stimulation through environmental enrichment increased the production of NGF in the brain.

This increase in NGF levels was associated with enhanced learning and memory performance (98).

7. Social Interaction

Positive social connections and experiences can also promote the release of NGF.

In one study, researchers found that mice raised in a socially enriched environment had higher NGF levels in specific brain regions and exhibited improved social behaviors (100).

Follow-up studies also showed that environmental enrichment, including social interaction, increased NGF levels in certain brain regions and improved behavioral outcomes (101-102).

This is just one reason why it's essential to maintain a healthy social life.

So if you want to produce more NGF, my advice is to talk to people whenever you get the chance, and hang out with your friends and family as much as possible. I should probably be taking my own advice here because I’m an introvert and don’t socialize too much.

But even just connecting through social media can help. It doesn’t necessarily need to be in person, although that’s definitely better.

8. Acupuncture

Acupuncture, a traditional Chinese medicine practice, has also been shown to increase NGF levels.

In one study, researchers found that electroacupuncture increased NGF levels, which could be associated with reduced brain injury and improved functional recovery (103).

In another study, researchers found that acupuncture increased NGF levels in the brain, which was associated with improved cognitive function (105).

And then other research has shown that electroacupuncture increases the expression of NGF and other neurotrophic factors, which can then protect the brain from injury y (104).

I’m personally a really big fan of auricular acupuncture.

Auricular acupuncture is when needles are inserted into the ear. I’d recommend trying to find a health practitioner in your area who provides it, especially if you’re weaning off psychiatric medication.

It really helped me the first time I came off antidepressants. I was surprised. At the end of each appointment, my practitioner would secure small black seeds on my ear.

In my experience, ear acupuncture is more effective than regular acupuncture.

I also lie on an acupuncture mat at home to relax before bed.

9. Massage

Regular massages can help increase NGF levels by promoting relaxation and reducing stress.

In one study, researchers found that massage therapy enhances NGF concentrations (106).

In an animal study, researchers examined the effects of massage on nerve regeneration and functional recovery in rats with sciatic nerve injury.

They found that massage therapy increased NGF levels in the sciatic nerve, which was associated with improved nerve regeneration and functional recovery (107).

This is one reason why I regularly get a massage from a registered massage therapist.

Massage also reduces cortisol, increases GDNF, and stimulates the vagus nerve.

10. Yogic Breathing

Yogic breathing techniques help to calm the mind, reduce stress, increase focus, and promote relaxation.

They also appear to increase NGF levels.

In one study, researchers found that yogic breathing stimulates the expression of NGF in cognitively normal healthy volunteers (108).

11. Intermittent Fasting

Intermittent fasting is an eating pattern where individuals cycle between periods of fasting and eating.

It has been found to positively impact various aspects of health, including brain health.

Research suggests that intermittent fasting can stimulate the production of neurotrophic factors, such as NGF.

This can then result in improved cognitive function, increased neurogenesis, and enhanced neuronal plasticity.

In one study, researchers found that intermittent fasting increased the expression of NGF.

The increase in NGF was associated with improved cognitive function and reduced brain damage (109).

In another study, rats underwent intermittent fasting, and they exhibited increased NGF levels.

This resulted in enhanced neuronal survival and reduced brain degeneration (110).

I often eat all my food for the day within an 8-hour window, and then fast for the rest of the day.

The best way to start fasting is by eating dinner around 6, not eating anything after that before bed, and then eating a regular breakfast the next day. That should give you about 12-14 hours of fasting time.

12. Cold Exposure

Short-term exposure to cold temperatures, such as cold showers or ice baths, can also help increase NGF levels.

It does this by triggering the release of norepinephrine, a neurotransmitter known to stimulate NGF production.

In one study, researchers found that cold exposure increased the expression of NGF and other neurotrophic factors (111).

In a review article, researchers discussed the potential of cold exposure to stimulate neurogenesis (the growth and development of new neurons) in the adult brain.

The authors suggest that cold exposure can increase the production of neurotrophic factors, such as NGF. This then promotes neurogenesis and improves cognitive function (112).

To practice cold exposure, you can try taking cold showers or spending time in a cool environment.

But make sure you do so safely and within your comfort limits.

I personally take a cold shower every day.

During the winter, I’ll also go outside for short periods of time with hardly any clothes. It boosts my dopamine and increases my motivation.

You don’t have to be that extreme though.

You can start by finishing your next shower with one minute of cold water.

See how it feels, and then over time, increase the amount of time you turn off the hot.

It can be a bit painful.

But the beneficial effects end up being worth it.

Another way is to stick your face, hand or foot in ice cold water.

Or you can try cold plunges, cold baths and even cryotherapy if you want.

Find what works best for you and do it regularly.

13. Reduce Inflammation

Chronic inflammation can negatively impact NGF levels.

Researchers have found that interleukin-1β (IL-1β), a pro-inflammatory cytokine, decreases the production of NGF and other neurotrophic factors (113).

Interleukin-6 (IL-6) has also been shown to regulate the production of neurotrophic factors, such as NGF (114).

There are many causes of chronic inflammation, including infections, toxic mold, brain injuries, and leaky brain.

But one of the most common causes – and the one you have the most control over – is your diet.

That’s why I recommend following an anti-inflammatory diet and limiting foods that can trigger inflammation in the gut and brain.

You should also remove processed food from your diet, and increase your intake of vegetables, fruits, wild fish, grass-fed beef and organic chicken.

Check out my Free Grocery Shopping Guide for Optimal Brain Health for a full list of anti-inflammatory foods.

Other steps you can take to reduce inflammation include reducing stress, exercising regularly, improving gut health, treating infections and getting enough sleep.

Make sure you also check out this article for 23 effective ways to reduce inflammation in the brain

14. Increase BDNF

BDNF (brain-derived neurotrophic factor) is another growth factor that plays a crucial role in the growth and maintenance of neurons.

Activities and interventions that increase BDNF, such as exercise, may also help increase NGF levels.

Researchers often find that interventions that improve BDNF levels also have a positive impact on NGF levels.

For example, researchers have investigated the effects of exercise on the expression of BDNF and NGF in the brain.

Their results often show that exercise increases both BDNF and NGF levels (115).

Researchers have also found that cinnamon increases both BDNF and NGF levels in the brain (116).

This suggests a potential link between interventions that increase BDNF and those that also increase NGF levels.

I previously provided 31 ways to boost BDNF in this article.

15. Transcranial Magnetic Stimulation (TMS)

Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique.

It uses magnetic fields to stimulate specific areas of the brain.

By stimulating specific areas of the brain, TMS has effects on NGF levels.

Emerging research and studies have shown that TMS can modulate and increase the production and release of various neurotrophic factors, including NGF.

This then supports neuronal growth, synaptic plasticity, and overall brain function.

As a result, TMS has been approved for the treatment of various neurological and psychiatric conditions, such as major depressive disorder, obsessive-compulsive disorder, and migraine.

In one study, researchers investigated the effect of repetitive TMS (rTMS) on serum levels of neurotrophic factors, including NGF, in drug-resistant depressed patients.

The results showed a significant increase in serum NGF levels following rTMS treatment (117).

In another study, researchers explored the effects of rTMS on plasma levels of NGF and other neurotrophic factors in patients with amyotrophic lateral sclerosis (ALS).

The researchers found that rTMS led to increased NGF levels in these patients (118).

This increase in NGF may contribute to the therapeutic effects of TMS, such as improved mood and cognitive function in individuals with depression.

I don’t have any personal experience with TMS. I investigated it but never ended up doing it myself and never ended up needing it. It can sometimes help people who have treatment resistant depression. But I think it should be a last resort and other alternatives should be explored first.

The Best Foods and Nutrients To Increase NGF

16. Omega-3 Fatty Acids

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are vital for brain health.

They are considered “essential fatty acids”, meaning your body cannot create them and you have to get them from food or supplements.

They’re found in fish oil, and making sure you get more of them is one of the most important actions you can take to support your brain and nervous system.

Many studies show that they significantly reduce brain inflammation; improve memory, mood and cognition; and protect against mild cognitive impairment, dementia and Alzheimer's disease.

They have also been linked to increased NGF levels.

In one study, researchers demonstrated that DHA promoted neurite growth in hippocampal neurons.

They found that DHA treatment increased NGF secretion in the neurons, suggesting that the observed neurite growth might be mediated by NGF (50).

In another study, researchers found that DHA promoted the development of hippocampal neurons and enhanced synaptic function.

The authors suggested that the effect of DHA on neuronal development is likely mediated, in part, by its activation of the NGF receptor and downstream signaling pathways (49).

Omega-3 fatty acids can be found in fatty fish, walnuts, flaxseeds, and chia seeds.

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

17. Turmeric (Curcumin)

Curcumin, the active compound in turmeric, is one of my favorite natural compounds for the brain.

It has been found to improve memory and protect against neurodegenerative diseases.

One way it does this is by boosting NGF production.

Studies have shown that curcumin can increase the expression of NGF and its receptor (51).

In one study, researchers found that curcumin increased the expression of NGF in brain cells and increased the number of synapses formed between neurons (52).

Other studies have also shown that curcumin increases the expression of NGF in a dose-dependent manner (53-54).

Turmeric and curcumin are included in the Optimal Antiox supplement.

Since turmeric and curcumin are fat soluble, they are best absorbed when combined with a fatty meal or taken with fats like coconut oil or olive oil.

18. Green Tea (EGCG, Theanine)

Several studies have investigated the potential effects of green tea and its polyphenols on nerve growth and function, including their effects on NGF expression and activity.

Researchers have found that the polyphenols in green tea, particularly epigallocatechin gallate (EGCG), can help increase NGF production.

In one study, researchers found that daily consumption of green tea for 12 weeks improved cognitive function and increased NGF levels in older adults with mild cognitive impairment (57).

In another study, researchers found that EGCG increased NGF expression in a dose-dependent manner (56).

If you're not a fan of drinking green tea, you can opt for a green tea extract supplement containing EGCG to increase NGF production instead.

In fact, most studies use either green tea extract or EGCG rather than regular green tea.

It’s also important to keep in mind that the body isn't very good at absorbing EGCG from green tea and distributing it to the brain and other tissues.

That's why researchers often use large dosages of concentrated EGCG in their studies instead of green tea.

But unfortunately, large doses of concentrated EGCG have been shown to cause liver toxicity.

So you could supplement with large dosages of concentrated EGCG and see some benefits.

But you'd be damaging your liver at the same time.

Not good.

So what should you do? How do you absorb EGCG and get the amazing benefits of it without damaging your liver?

You take it with Vitamin C.

Research shows that you can enhance the absorption and availability of EGCG by taking it with Vitamin C.

That's why the Optimal Antiox supplement includes a small and safe amount of EGCG, plus 500 mg of Vitamin C.

This significantly enhances the absorption of EGCG, and ensures you get all the brain and mental health benefits of EGCG (without the harm).

Theanine, which is an amino acid found in green tea, has also been shown to increase NGF (55).

Theanine is included in this supplement.

19. Magnesium

Magnesium is an essential mineral that plays a key role in nerve function.

It also plays a critical role in regulating the activity of ion channels in nerve cells, which are important for transmitting signals between nerve cells.

Research shows that magnesium supports NGF secretion and promotes the regeneration of nerve axons after central nervous system injury (58-60).

There are a number of things you can do to make sure you’re getting enough magnesium.

First, make sure you’re eating magnesium-rich foods on a regular basis, including:

Spinach
Chard
Pumpkin seeds
Almonds
Avocado
Dark chocolate
Bananas

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

You can also increase your body’s intake of magnesium by taking Epsom salt baths.

Supplementation is often a good idea for most people.

You can find magnesium in the Optimal Energy supplement.

20. Zinc

Zinc is an essential trace element that plays a crucial role in overall brain health and function.

It is involved in numerous cellular processes, such as enzymatic reactions, gene expression, and protein synthesis.

Zinc is also necessary for the proper functioning of the nervous system and has been shown to influence synaptic plasticity, learning, and memory.

Zinc has been linked to increased NGF levels.

In one study, researchers found that zinc supplementation had a positive effect on NGF expression in the brain (61).

Another study also found that zinc supplementation Increases NGF (62).

I created and take the Optimal Zinc supplement to make sure my zinc levels are optimal. I created it because I want to give my readers the very best zinc supplement so that they can experience superior results. I have found that many zinc supplements on the market fall short. Optimal Zinc includes several other nutrients and co-factors that increase the absorption of zinc.

Besides supplementing with zinc, you should also eat plenty of healthy, whole foods that contain zinc.

Some of the best foods to optimize your zinc levels include:

Oysters
Grass-fed beef
Pumpkin seeds
Cashews
Mushrooms
Spinach

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

21. Lion's Mane Mushroom

Lion's mane mushroom (Hericium erinaceus) is a fungus that has been traditionally used in Chinese and Japanese medicine for cognitive enhancement and nerve health.

This edible mushroom has been shown to support overall brain health by promoting neurogenesis and stimulating NGF production.

Several studies have explored the effects of lion's mane mushroom on NGF.

In one study, researchers found that lion's mane mushroom had neurotrophic effects and was able to stimulate the production of NGF (63).

Another study showed that compounds called hericenones, isolated from the lion's mane mushroom, were able to increase NGF synthesis (64).

Researchers have identified two active compounds, erinacines A and C, which contribute to the mushroom’s NGF-inducing activity (65).

Other research has shown that lion's mane mushroom mycelia extracts, which are rich in erinacines, promoted NGF synthesis and protected against neuronal damage (66).

Lion’s mane mushroom extract is also available as a supplement in capsule or powder form.

22. Resveratrol

Resveratrol is a natural compound found in red wine, grapes, and berries that has antioxidant, anti-inflammatory and neuroprotective properties.

It has been shown to increase GDNF, help restore the integrity of the blood-brain barrier, and support your mitochondria.

It can also help support NGF production.

In one study, researchers found that resveratrol increased the expression of NGF in the brain (67).

Researchers have also investigated the effects of resveratrol on NGF and its receptor, TrkA.

They have found resveratrol increased the levels of NGF and TrkA in the brain (68).

To consume enough resveratrol to increase NGF, you’ll need to supplement with it.

Resveratrol can be found in this supplement.

23. Cinnamon

Cinnamon is a tasty spice that has a number of health benefits.

It has been found to have positive effects on NGF levels in the brain.

In one study, researchers investigated the effects of cinnamon on the levels of neurotrophic factors, including NGF.

They found that cinnamon led to an increase in NGF levels in the brain (116).

Not all cinnamon is created equal though.

You’ll have to find and consume Ceylon, which is considered “true cinnamon”. It has the most health benefits.

Most cinnamon in grocery stores is cheap and not actually Ceylon.

You can usually find Ceylon in health food stores.

The Best Natural Supplements and Herbs To Increase NGF

24. Alpha Lipoic Acid

Alpha lipoic acid (ALA) is a naturally occurring antioxidant found in certain foods.

It is also produced by the body, playing a role in mitochondrial energy metabolism.

It has been studied for its health benefits, including its neuroprotective effects.

In supplement form, it is a potent antioxidant compound that has been shown to improve cognition.

It reduces oxidative stress and inflammation in the brain, which can contribute to neurological decline.

It also helps regulate blood sugar levels, which is crucial for healthy brain function

Researchers have found that ALA increases NGF production as well.

In a review article, researchers mention that ALA has been shown to increase the expression of NGF in the brain (69).

In one study, diabetic rats treated with ALA showed increased NGF levels in their sciatic nerves.

The researchers concluded that ALA could have a positive effect on neuronal health and function (70).

Another study showed that ALA protected dopaminergic neurons against apoptosis.

ALA's protective effect was associated with increased expression of NGF and other neurotrophic factors (71).

Alpha Lipoic Acid can be found in spinach, broccoli, and organ meats like liver and kidney.

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

But ALA is more commonly taken as a supplement.

ALA supplements are fat soluble and can easily cross your blood-brain barrier.

ALA can be found in the Optimal Antiox supplement.

25. Acetyl-L-Carnitine

Acetyl-L-carnitine (ALCAR) is a naturally occurring compound derived from L-carnitine.

It’s involved in energy metabolism and the transport of fatty acids into the mitochondria.

ALCAR has been studied for its neuroprotective effects and ability to enhance cognitive function.

It’s often used as a natural brain booster by people of all ages because it supports brain cells and increases alertness.

It’s also been associated with increased NGF levels.

In one study, researchers found that ALCAR resulted in increased NGF levels in the brain.

It also increased the activity of choline acetyltransferase, which is an enzyme involved in the synthesis of the neurotransmitter acetylcholine (72).

In another study, rats were treated with ALCAR.

The treatment resulted in increased NGF levels and choline acetyltransferase activity in the brain (73).

Regular carnitine is found in red meat, dairy products, and avocados.

But for best cognitive-enhancing results, ALCAR needs to be taken as a supplement.

I find that ALCAR personally gives me a big boost in cognitive energy and resilience. It keeps me motivated to do complex tasks that require optimal brain function.

That’s why it’s included in the Optimal Brain supplement.

Make sure you read this article to learn more about the remarkable benefits of ALCAR.

26. Ginkgo Biloba

Ginkgo biloba, an ancient tree species, has long been used in traditional medicine for its health benefits.

Ginkgo biloba extracts have been studied for their antioxidant, anti-inflammatory, and neuroprotective properties.

It’s also been shown to improve memory and enhance cognitive function.

One way it does this is by increasing NGF levels.

In one study, researchers found that Ginkgo biloba increased the expression of NGF in the brain

The increase in NGF levels was associated with enhanced neurogenesis and improved cognitive function (74).

Another study demonstrated that Ginkgo biloba protected human neuroblastoma cells from cell death.

The protective effect was associated with the upregulation of NGF expression (75).

My Optimal Brain supplement contains Ginkgo Biloba, along with other premium ingredients that protect the brain and enhance cognition.

27. Phosphatidylserine

Phosphatidylserine is a naturally occurring phospholipid found in the cell membranes of neurons and other cells.

It plays a critical role in maintaining membrane fluidity, regulating cell signaling, and supporting neurotransmission.

High amounts of phosphatidylserine are found in the brain, and supplementation has been shown to improve attention, learning and memory.

Studies have shown that phosphatidylserine can also enhance the production of NGF and other neurotrophic factors.

In one study, researchers found that phosphatidylserine increased the release of NGF (127).

Another study showed that phosphatidylserine supplementation led to enhanced NGF receptor expression and improved cognitive function (128).

Phostadidylserine is included in the Optimal Brain supplement.

Make sure you read this article to learn more about the remarkable benefits of Phosphatidylserine.

28. Gotu Kola

Gotu kola (Centella asiatica) is an herb that has been used in traditional medicine systems for its cognitive-enhancing and neuroprotective properties.

Some research suggests that Gotu kola has a positive effect on NGF levels.

In one study, researchers found that oral administration of Gotu kola significantly increased NGF levels in the brain.

The researchers suggested that the increased NGF levels might contribute to the memory-enhancing effects of Gotu kola (129).

Another study demonstrated that Gotu kola promoted neurite outgrowth. This effect was partly mediated through the activation of the TrkA receptor, which is the primary receptor for NGF (130).

It's important to point out that the Gotu Kola plant soaks up heavy metals from the soil. So you need to find a high-quality, organic source that doesn’t contain heavy metals.

29. Bacopa Monnieri

Bacopa monnieri, also known as Brahmi, is a traditional Ayurvedic herb known for its cognitive-enhancing and neuroprotective properties.

It has been found to support memory and overall brain function. .

It’s also been shown to promote NGF production.

In one study, researchers found that Bacopa monnieri increased the expression of NGF in the brain.

The increase in NGF levels was associated with improved cognitive function and memory consolidation (76).

In another study, treatment with Bacopa monnieri protected against oxidative stress and neurotoxicity.

The neuroprotective effect was associated with an increase in NGF expression (77).

Besides improving memory and cognition, I have found that bacopa is very relaxing and good at reducing anxiety and stress.

So it’s a good option if you’re looking for something to increase NGF and relieve anxiety at the same time.

30. Ashwagandha

Ashwagandha (Withania somnifera) is another adaptogenic herb commonly used in Ayurvedic medicine.

Its health benefits include stress reduction, cognitive enhancement, and neuroprotection.

Ashwagandha has also been shown to increase NGF levels.

One study demonstrated that withanolide A, a bioactive compound found in ashwagandha, promoted neurite outgrowth in neurons.

The neurite outgrowth was accompanied by an increase in NGF expression.

The researchers concluded that ashwagandha can support neuronal regeneration by modulating NGF levels (78).

In another study, ashwagandha supplementation resulted in a significant increase in NGF levels in the brain.

It also increased antioxidant enzymes in the brain.

This study suggests that ashwagandha has neuroprotective effects by modulating NGF expression and reducing oxidative stress (79).

Ashwagandha is one of the main herbs I took to reduce stress and anxiety, and restore balance to my brain and body, after I came off psychiatric medications.

31. Rhodiola Rosea

Rhodiola Rosea is an adaptogenic herb that has been used for centuries.

It’s one of the most popular adaptogens used to increase physical and mental stamina.

It helps the body adapt to stress, reduces fatigue, and enhances cognition.

It also has a positive impact on NGF levels.

Salidroside is one of the primary active constituents of Rhodiola rosea.

In one study, salidroside had neuroprotective effects by upregulating the expression of NGF (80).

I take rhodiola when I need an extra boost in brain function and cognitive energy. It’s especially useful after stressful periods of pushing myself too hard. It helps me recover faster.

Rhodiola also boosts acetylcholine and dopamine levels, and induces autophagy in the brain.

Be sure to check out this article to learn more about the benefits of rhodiola.

32. Probiotics

Gut health is closely connected to brain health, and there is growing evidence that probiotics can influence brain function and neurochemistry.

Some studies suggest that probiotics can support NGF production.

In one study, researchers investigated the effects of chronic administration of Bifidobacterium longum on anxiety, memory, and neurogenesis.

The results showed that B. longum increased NGF levels and improved memory performance (81).

B. longum is included in the Optimal Biotics supplement.

Another study looked at the effects of Lactobacillus plantarum on depression and anxiety-like behavior in mice.

The results showed that L. plantarum alleviated depression-like behavior and significantly increased NGF levels (82).

To support your microbiome and increase probiotics in your gut, you can eat probiotic-rich foods like yogurt, kefir, sauerkraut, and kimchi.

You can also take a probiotic supplement, such as Optimal Biotics.

Check out this article for several other ways to increase your good gut bacteria.

And if you struggle with anxiety or depression, here are 9 probiotic strains that can help.

BONUS: Emerging NGF-Enhancing Drugs and Treatments

Several emerging drugs and treatments are being developed and investigated for their potential to enhance NGF levels or promote its activity.

While some are still in the preclinical or early clinical stages, they represent potential avenues for future therapies.

Some of these drugs and treatments include:

NGF gene therapy: This approach involves the delivery of the NGF gene directly into the target tissue, such as the brain, to promote NGF production. Various methods, such as viral vectors, have been investigated for efficient gene delivery. Early studies have shown promise in animal models of neurodegenerative diseases, such as Alzheimer's disease (119).

Small molecules targeting TrkA receptors: Tropomyosin receptor kinase A (TrkA) is the primary receptor for NGF. Small molecules that target and activate TrkA receptors could potentially mimic the effects of NGF and promote neuronal survival, growth, and function. Several compounds have been investigated for their potential to activate TrkA receptors (120).

Peptides mimicking NGF: Researchers are developing peptides that mimic the structure and function of NGF. These peptides can bind to TrkA receptors and activate downstream signaling pathways, similar to NGF. These peptides have shown promise in preclinical studies as a potential therapy for neurodegenerative diseases and nerve injuries (121).

Stem cell therapy: Stem cells can be coaxed to differentiate into specific types of cells, including neurons. Researchers are investigating the potential of stem cell therapy to promote neurogenesis and neuronal survival, which could be partially mediated through NGF enhancement (122).

P7C3 and its derivatives: P7C3 is a small molecule that has been shown to enhance the production of NGF and support the survival of neurons. P7C3 and its derivatives have demonstrated neuroprotective effects in animal models of neurodegenerative diseases and may hold potential for further development (123).

LM11A-31: LM11A-31 is a small molecule that targets the p75 neurotrophin receptor (p75NTR), which interacts with NGF and other neurotrophins. This compound has been shown to promote neuronal survival and neurite outgrowth in preclinical studies, and it has undergone phase 1 clinical trials for Alzheimer's disease (124).

Cerebrolysin: Cerebrolysin is a peptide mixture derived from pig brain tissue that has been shown to have neurotrophic effects, including the enhancement of NGF expression. It has been studied in clinical trials for Alzheimer's disease, stroke, and traumatic brain injury (125).

Dihexa: Dihexa is a small molecule that has been shown to promote the formation of new synapses and enhance cognitive function in animal models. It is thought to enhance neurotrophic signaling, including the activation of NGF receptors. Dihexa is in the early stages of research and has not yet undergone clinical trials (126).

It is important to note that many of these emerging drugs and treatments are still in the early stages of research and may have limitations and side effects. Further research is needed to fully understand their potential therapeutic effects, safety, and optimal application.

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